I think it will get even less coverage, as I doubt we will still have the Big Three networks having a dinner hour news broadcast in ten years. The news media will be so splintered, that websites like this one, will be one of the few that will be recognizing that achievement. I recorded as much of the newscasts from this year, assuming this will be the last major celebration with 1960s era news media, i.e. TV, Radio, and print newspapers.
I believe the ISS will be still around for another 15 years, will be fixed up or even further modified with new modules. The COLBERT, oops, I mean Tranquility Module, has four free ports for expansion, as an example.
I noticed that private sector-based options haven't been discussed. I think we will see a lot from private industry in low Earth orbit in 10 years. Including manned flights routinely to the ISS by ships like SpaceX's Dragon doing most of the North American workload of supporting astronaut transfers to and from orbit. Also, there have been news reports in the past few years that a private Moon circumnavigation flight could be performed with only slight modifications to the current Soyuz spacecraft, so tourists might be able to circle the moon, a la Apollo 13 style (no explosions, just its trajectory), well before the 50th anniversary, yet no one will likely have walked on its surface in that time. Cost for the flight per tourist astronaut will be at least $100 million USD.
The Moon probably will still be uninhabited by humans, though it now seems more likely that China or India will get back there before NASA.
I would also say that at least half of the current surviving crop of moonwalkers will still be around for the 50th, but few or none will be around for the 60th (they'd all be in their very late 90s or centenarians by then).
The only bright spot with NASA I see is in a mission that actually by-passes the moon, and goes straight to Mars, using the ideas presented by the Mars Society. For the amount of money it seems that they will be spending on Constellation, they could go to Mars instead.
More optimistic than most views on this forum, but I do believe there will be a manned American presence in space for most of the next ten years, with a slight chance that NASA will again leave low-Earth-orbit. Oh, and that NASA will indeed still exist on the 50th Anniversary.