I am not a chemist.<br /><br />But what I have read, in literature about the possiblility of alien life, is that the complexity we see in higher life forms on earth require a vast number of chemical combinations and interactions. Imagine how many types of protiens, enzymes, hormones, interactions etc are required to make a human being function.<br /><br />The possible interactions between hydrogen, oxygen, and carbon are incredibly huge, primarily due to the characteristics of carbon, which has the ability to connect to a rather large number of other atoms simultaneously.<br /><br />For this reason, I think it is entirely possible that life may be possible with other chemical compositions, but it will probably have a slower, less effective metabolism, and probably be more simple. <br /><br />In addition, cold climates would have less energy available to drive life processes.<br /><br />For example, if there are seas on Titan, they may contain large, simple bacteria. I wouldnt think there would be much more.<br /><br />I would completely rule out creatures that live in extreme hot fluids like lava, for example, because the interactions between materials high temperature liquids are supposedly relatively simple.