Yes, a negative result is informative. This is what SETI gave us. At one time people thought that if we had a sensitive radio telescope, we would hear a "galactic Internet" where all the civilizations of the galaxy communicate with each other. We now know there is no such thing as that. But there was a time when we did not know, so science advances. We know now that advanced civilization that uses radio is at least extremely rare or it is possible we are the only ones.
It looks like now by the 2040s we will know if life itself is very rare or common.
My prediction: We will find the bacteria-like life is relatively common but more advanced live is very rare and we might be the only example of it. We might know in only 20 or 30 years