TC_sc:
I believe VASIMR only accelerates at a fraction of a gee. Either some sort of artificial gravity would be required - OR, since ISS astronauts routinely stay aloft for 6 months at a time, it doesn't seem like astronauts would be incapacitated on the surface of Mars (at only 1/3 G) after only a 49 day flight. Depending on their stay time on Mars, they may need to be reconditioned before returning to Earth, but this may be able to be done in a centrifuge (in a space station?) in Earth orbit.
Also, VASIMR refers only to the plasma-generating and acceleration system; it does require a power source (in the Ad Astra lab on Earth, it uses the Houston municipal electrical grid). A NTR reactor would be a perfect power source, and (as you wrote), with bimodal design, could produce electrical power when the plasma drive was off.
The Russians have designed solar-ion propelled Mars ships with truly immense solar panels. I honestly have no idea how the power demands of VASIMR compare with ion propulsion, so I don't know if solar power is even an option for VASIMR. Does anyone know?
Let's not forget radiation shielding. I think that a double-walled module, with water filling the space between the walls, might work. The astronauts need water anyway, for drinking, washing, cooking and cooling. It would be ironic, though, if something happened to the inside wall; the first astronauts to drown in space?...Maybe some sort of hydrogen-rich foam would be better, and lighter.