EarthlingX,
You have fallen into the trap which commonly gets most people considering my concept. They try to envision the Space Shuttle, fully fueled, sitting on top of a carrier wing, and boggle at what they see. So would I. The Space Shuttle is a vehicle designed to carry a large (physically and pound-wise,) payload to altitudes as high as 600 miles. It is designed for vertical take-off, so it has very large engines, which consume huge quantities of fuel. The airframe is entirely metal, and was designed with a very conservative attitude, seeing as no one had ever flown anything like it.
So, toss that image of the Space Shuttle riding on the back of a wing out the window, and imagine a much lighter vehicle, perhaps about the same size as the Shuttle, but with internal tanks instead of a payload bay. Or, a payload bay which is much smaller, accommodating a 15 passenger van-sized life support module instead of a city bus. This vehicle is built primarily of composites, and the engines are much smaller, although there might be more than three of them. Because the vehicle never has to climb straight up against gravity, total thrust to weight ratio of less than 1 to 1 is acceptable, but a ratio of .75 to 1 is desirable.
Total vehicle weight at separation would be on the order of 1 million pounds, but probably more like 750,000. That seems like a lot, but we are carrying large fractions of that amount half way around the world using conventional aircraft with only four engines. Using a specially designed airframe, and as many as 12 engines, plus a catapult to accelerate the stack to take-off speed, I am confident that we can lift a payload of 1.5 million pounds to 50,000 feet. Going any higher reduces the efficiency of the carrier wing, while imparting little benefit to the orbiter.
All of my figures are guestimates, based upon actual weights and capabilities of existing vehicles.
Space shuttle orbiter: Empty weight 172,000 pounds Maximum payload 55,000 pounds Gross lift-off weight 240,000 pounds Payload bay 15 X 59 feet Service ceiling 600 miles On-orbit endurance 14 + days with crew of 7.
External tank: 534,900 gallons Gross lift-off weight 1,670,000 pounds.
This is considerably different than a vehicle with a service ceiling of 140 miles, and a payload of 2,500 pounds, which has an on-orbit endurance capability of only 72 hours.