The big problem is vehicle average Isp. Standard rocket fuel Isps, even LH2/LOX, do not provide enough fuel efficiency to get vehicles into orbit in one stage AND make them returnable to earth with a TPS. LH2/LOX fuel combination (450 sec Isp) requires a .89 mass fraction (i.e. 89% of a launch vehicles gross liftoff weight is propellant) or higher to get into orbit. This means all the structures, payloads, thermal protection system, engines, etc needs to come to no more than 11% of the GLOW.<br /><br />The problem is that rockets with no thermal protection for reentry have difficulty meeting this requirement.<br /><br />If, instead, you find a way to get higher Isp, you can use airframe structures that are more normal to the aviation industry, and include thermal protection in the airframe. For example, with an Isp of 505 seconds, you only need a mass fraction of .78. <br /><br />Nuclear propulsion has been proposed in the past for this reason, as it offers Isps of 600-1000 seconds: certainly more than enough to reach orbit in one stage and have a TPS and a payload and be manned. But of course, the radiation hazard makes this politically untenable.<br /><br />It turns out, though, that airbreathing engines, like turbines, ramjets, scramjets, get much higher Isps, between 1500-6000 sec, because they don't carry their oxidizer, they use the oxygen in the atmosphere, so because of that, the mass of the atmospheric oxygen doesn't need to be included when calculating Isp, or included in the fuel mass for the vehicle, so your LOX tank is much smaller and lighter. If you can operate your engines in a ramjet or scramjet mode for the lower third of a launch vehicles flight regime (mach 1-8.5), using the same fuel, you should be able to at least double the average Isp for the entire flight.<br /><br />This is why the X-43A program was so important, and ramjet/scramjet propulsion in general: it is the only way we are ever going to develop reusable single stage to orbit launch vehicles t