I grew up reading a lot of fascinating and imaginative science fiction. One picture some painted was a permanent, self-sustaining manned colony on Mars, something that appeared realistic and romantic. I do hope that one day it comes to pass. That's my utimate goal, the end game for the beginning of mankind's steps out of our local solar system and eventual travel to far stars.
Right now only Mars or the Moon appear as the only celestial bodies we are capable of reaching, any other canditates such as Europa are just too far away, and anyways, we need to be able to master Mars before trying to extend our reach.
I have carefully read all posts in this thread, and although very informative and entertaining, almost all posters have operated on the assumption that space exploration is a vacuum occupied solely by the USA. But external forces and politics will most likely be the factors that determine who first steps on Mars, and when.
India and China have roadmaps for eventual manned missions on Mars. Russia does not presently have a roadmap or hard plans for a manned mission to Mars, but if there's a way, they will go for it. Other nations such as the EA, Japan, Brasil, and Canada have modest ambitions too, and are willing to be involved or partnered in such proposed missions.
The scenario I see unfolding is that the USA is stuck in internal bickering and stagnate until another nation has begun serious work towards a manned Martian mission. Then, and only then will the population become interested and motivated, and the politicians involved enough to give proper support towards a manned mission to Mars. Once again, competition against another nation for national pride would be the driving force, as it was in the Moon race.
On the political roadmap, Mars would be the target. But as mentioned before, the military has a big voice in determining the direction space exploration and budget money goes. And for them, Mars means nothing. Low earth orbit is the battleground, and the Moon is considered the high ground. Although it appears that it is impractical to fight from the Moon, it has other uses, such as a base for reconnaissance, and if nothing else, to deny any potential enemy the Moon. It's not as much as what the US military can do from the Moon, but the potential and imagined threats other hostile nations can develop and impliment from the moon.
Space exploration is best done by small steps, this is the proven method. For instance, all the Gemini missions were just preparation for Apollo. Such skills such as rendezvous, docking, and spacewalks were learned by Gemini, each one step at a time. The ISS just didn't spring up overnight, such missions such as Skylab and Mir paved the way. The same applies to the Moon or Mars. We have been to the Moon, and it would be easier to re-learn the lessons from Apollo and get back to the Moon than to go to Mars.
Mars is a huge step, and I do wonder whether our reach exceeds our grasp at present.
I also question whether it is valid to risk the lives of human beings, do they have to go to Mars when we may have robots that can fulfill the mission requirements?
Notwithstanding my comments, it will be politics and external forces that will drive any effort by the USA to go to Mars or the Moon. But because some other nation(s) have Mars firmly on their sights, the USA will be forced to compete against them, because of national pride. Then, just as in the days of Apollo, public interest will dissipate, and the competitors will be the ones to establish a permanent, self-sufficient Mars colony. Probably the Chinese.