There have been significant periods when the ISS was controlled from Russia; although this is now done with US computers. What will actually happen if the US says it is withdrawing vital support? International cooperation with the US will be out the window forever, particularly if the US spitefully refused to provide the information required to keep it functional. This would simply be a flagrant violation of an international agreement.<br /><br />Personally I don't think the US will withdraw. We proposed the ISS with numerous claims that, using it, humans would perform useful and productive work in space, and I believe if we are as smart as we claim, we can do just that. I'm speaking only for myself, but if, after spending $100,000,000,000 of the taxpayer's money, we can't find anything worthwhile to do on the ISS, than I think the taxpayers would be extremely unwise to give us another $100,000,000,000 to do the same thing on the moon.<br /><br />With all the ISS "Utilization" flights off the schedule, it may be a challenge to get experiments up there, but the original proposal included both astronomical observation (using co-orbiting free-flyers that would periodically dock with the ISS for servicing) and earth observation (using sensors simply mounted externally on the truss). In fact, I believe the potential for earth observation was one of the reasons for the bearings that allow the inner station to fly in local-vertical attitude, facing the earth, rather than solar-inertial, facing the sun, which was required, for the most part, for Skylab and Mir because of their fixed solar panels.