Agreed.One of the things that ChrisA talks about is the expense of the engineers to design, build, test and operate a scientific payload. But, with wider body launch vehicles that can loft heavier packages, the difficulties in doing that work for a specific mission goal can be reduced, potentially by a lot.
Of course, the asperations of scientists will also increase to utilize whatever we can get into space, so the net result may be just more results for the cost level that we can afford. Think big telescope that does not need to be folded and unfold automatically a million miles away, vs an even larger telescope that does need to unfold, but gets even better data.
However, there is also the potential to actually assemble an even bigger telescope in low earth orbit and then boost it out a million miles. Putting the ability to do final mission vehicle and instrument package assembly of prefab components into low earth orbit and being able to refuel it there is likely to be the biggest game changer for costs, and reliability.
Also, there is an opportunity for new mission architectures.
Imagine a swarm-based mission to jupiter with a variety of single function sensor cubesats reporting not to Earth but to a Starship-based mother ship in high Orbit. Instead of each cubesat needing a powerful storage and communication system to send data to earth, it could feed their data to the mothership which could host a big AI control system, massive antennas, and a micro nuclear reactor to relay the data streams to Earth.
Consider New Horizons: it cost $700M in 2006 dollars, $1.1B in 2024 dollars.
A Starship-based mission could carry 100 $5M cubesats and $100M in launch costs and still have $500M for the mothership customizations.
With a common modular bus design and lower weight restrictions, the swarm can be better shielded without requiring expensive radiation hardened components.
Or, consider that SpaceX gets their half centimeter landing accuracy by leveraging GPS, how about giving the moon and mars their own combo GPS/Starlink constellation? Starlink satellites are estimated to cost less than $200K and all that would be needed would be a couple dozen.
Or, how much would a farside lunar-crater version of the late, lamented Arecibo observatory weigh/cost? One launch, one landing.
The money saved from not using SLS's "best 20th century" tech can be better applied to useful payloads on a single mission.
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