*Gene Roddenberry joked in an interview shortly after "Q Who" that the planet seen by Spock might have been the Borg homeworld. (Star Trek Encyclopedia) This idea was further developed in the William Shatner novel The Return, where Spock's mind meld with V'Ger not only protected Spock from being assimilated (since the Collective was already present in Spock's mind, the Borg assumed he was already one of them), but provided the Federation with the coordinates of the Borg homeworld for a final attack.
It is also interesting to note that Spock, when referring to V'Ger, said, "resistance would be futile." In the game Star Trek: Legacy, it's said that V'Ger itself created the Borg to gain the knowledge by assimilation. However, in the Star Trek Voyager episode "Dragon's Teeth", the character Gedrin states to Seven of Nine that his species, the Vaadwaur, had encountered the Borg over nine centuries prior to his revival. This would place their genesis at least as far back as around the year 1400 AD. It should also be noted, however, that the story writers for Star Trek Legacy claimed on the official game forum that Voyager 6 was meant to have been thrown back in time as well as across the galaxy, an aspect mentioned in the "extras" cutscenes of the game itself.
* The concept of V'Ger, an Earth-launched space probe that becomes a powerful, sentient being in its own right, is in many ways a re-visiting of the Nomad probe featured in the original series episode "The Changeling".
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* When Spock attempts the mind-meld with V'Ger and is quickly overwhelmed, among the images visible on the screen multiple times, when in slow motion, amid the background of his face, can be seen the dedication plaque carried not by Voyager 1 and 2, but by Pioneer 10 and 11. Other images include a Klingon cruiser seen earlier, the bridge and two crew members of (presumably) the IKS Amar, Epsilon IX, the Epsilon IX lieutenant, and Ilia.