I've run the numbers on interstellar travel within a human lifetime and it boils down to this: ....
Providing the universe is just as completely inertially inert as you make it out to be, Bill. Me, I believe it is just as inertial-less -- thanks to a
seemingly accelerating expansion of the universe to a
seeming infinite nowhere (an intersecting gravitational wave interface physics (fractal zooms universe structure)) without any point-singularity -- as it is locally inertial (the singularity is a quantum physic, not a gravity physic). That alone changes the picture of SPACE FRONTIERS and the timely ability of (potential fusion or otherwise) powered flight (constant accelerations) to get around . . . to superconduct and/or just go freer of any drag, any inertia . . . in them.
Since the constant of the speed of light, 'c'.is a
"go with" constant, it is no limiting barrier to an ever expanding, ever-increasing, distance-speed in a self-accelerating gravity wave hopping and surfing (hyperspace interfacing) drive. Also, distant observers at any distance will never observe travelers except within the framework of a Heisenberg uncertainty principle-like scenario of "if you know the velocity, you cannot possibly know the position" / "If you know the position, you cannot possibly know the velocity."
And if the observer observes a distant image -- at any distance -- traveling close to the speed of light, the likelihood is that the objectively real on the spot is, or was, far ahead of the observed image in distance and speed and traveling beyond the speed of light
relative to the observer! The universe splits in two or more universe spaces / spatial universes and past-future (clock) times (image in the 'past' frame / real in the 'future' frame).