Good question. Here's my list<br /><br />1 GEOLOGY/GEOPHYSICS<br /><br />1.1 Polar ice deposits - do they exist, how extensive, what is their age, what is their thickness, how do they form, what is their composition, are they a potential resource? Some questions may be answered by rovers and sample return missions, but full investigation will require astronauts on site.<br /><br />1.2 Aitkin Basin - does it really reach down to the lunar mantle, what has been its influence on lunar crustal and regolith evolution, what does it tell us about the evolution of the lunar interior? Probably answerable by a sample return mission possibly with a rover to collect samples. However as the region is also of interest because of possible ice, it is an ideal target for human missions.<br /><br />1.3 Lunar transient phenomena - do they exist, what is their composition, how are they triggered, what do they tell us about lunar volatile inventories, is there a link to volcanism, are they pointers to lunar resources? Sites like Alphonsus, Aristarchus would be a good place to start. Possibly preliminary visits by rovers, with follow up by human missions.<br /><br />1.4 Farside highland crust - is it different in composition from nearside crust? Could be answered by sample return missions, high capability rovers, or human exploration.<br /><br />1.5 Farside mare basalts - are these small, isolated maria different in detailed composition to nearside maria? Again could be answered by sample return missions, high capability rovers, or human exploration.<br /><br />1.6 Solar wind flux - because the moon passes through the earth's magnetotail as it orbits and it is tidally locked with one face to the earth, different parts of the moon get very different levels of exposure to the solar wind. Questions - how does the predicted flux compare with measured, are the regional variations in implanted solar wind materials in the regolith, what implications does this have for lunar facilities, are there <div class="Discussion_UserSignature"> <p><em>Whether we become a multi-planet species with unlimited horizons, or are forever confined to Earth will be decided in the twenty-first century amid the vast plains, rugged canyons and lofty mountains of Mars</em> Arthur Clarke</p> </div>