What Nacund said. The ET contains the fuel for the Main Engines (the ME in MECO). ET separation is going to cause MECO one way or another. The right way, MECO happens before ET separation, you leave a little bit of unused fuel in the ET but who cares. The wrong way, the ET separates, the main engines shut down from starvation, but more importantly, the ME's turbopumps run dry. Imagine driving your car down the highway with the pedal to the floor, then suddenly kicking into neutral. Except instead of overheating and pulling to the side of the interstate, the turbine flies apart and tears up the tail of your spaceship.<br /><br />That's why on the last shuttle launch they had to keep swapping the external tank. There are sensors in the tank to tell you when the tank is just about empty, so that if you haven't reached MECO yet, it forces a kind-of-safe early MECO instead of a very-not-safe pump explosion. Some of those sensors were faulty.