The biggest risk to an astronaut on EVA would be depressurization of the suit. A very small leak might be survivable, or temporarily pluggable (eg with a finger) but a big hole could be fatal fairly rapidly, not least becuase depressurization will quickly render the astronaut unconscious and unable to assist in his/her rescue.<br />.<br />Sidenote: the safest orientation with respect to MMOD which shuttle_guy mentioned is upside down and tail first. Tiles are exposed, but damage to those is less likely to be instantly fatal. The delicate RCC panels, however, are protected, as they face forwards (or, during orbital ops, backwards -- away from the direction of travel). The idea is to use the massive (and at that point relatively expendable) SSMEs as a shield. They face into the direction of travel.<br />One exception to this: the Orbiter has no control over its orientation while docked to the ISS. It is at the whim of the station. The station's orientation is such that the Orbiter will travel belly-first. If memory serves, while docked to the forward port of Destiny, the Orbiter's tail is pointing "down" (towards Earth) and the nose is pointing out into deep space.<br /> <div class="Discussion_UserSignature"> <p> </p><p><font color="#666699"><em>"People assume that time is a strict progression of cause to effect, but actually from a non-linear, non-subjective viewpoint it's more like a big ball of wibbly wobbly . . . timey wimey . . . stuff."</em> -- The Tenth Doctor, "Blink"</font></p> </div>