Back in 1976 the Viking Landers carried out 3 experiments on soil samples on Mars.
One of these was the Labelled Release, in which a liquid containing 7 potential nutrients tagged with Carbon-14 was added to the soil sample. The air above the soil was monitored to see if there was any radioactivity detected, which could be the result of microorganisms having metabolised the nutrient.
With both landers, this produced a positive result.
The soil samples were then heated for 3 hours and the test repeated. If the heating had killed off any life then no result would be produced.
This is exactly what happened!
However, the other two experiments - a gas chromatograph mass-spectrometer and the gas exchange - failed to give positive results.
It is now believed that the GCMS was limited in its ability to detect certain types of organic molecules at low concentrations, which could have meant it missed potential organic matter even if it was present.
So if its results are ignored, it is quite possible that we actually did find evidence of life on Mars almost 50 years ago!
The big question is of course why the experiments have never been repeated by more modern craft ...
Jerry Stone FBIS FRAS, Freelance Space Presenter