While we may be the only technological species in the Milky Way Galaxy, or perhaps one among a handful, I would dare not presume that we're the only one in the entire Universe!
Life itself is probably fairly common, but relatively rare. I know that sounds like a contradiction, but let me explain:
Life itself, as we know it and don't know it, is probably fairly common. Bacteria, algae, viruses, 'green slime' and other micro-organisms may be prolific. But big animals, like dinosaurs, reptiles, birds and mammals may be comparatively rare.
And intelligent creatures like dolphins, elephants, octupuses, crows, parrots and owls, cats and dogs, may be even more rare. And intelligent creatures like humans, who can build spacecraft, radio telescopes and toasters, may be EXTREMELY rarer still!
But even if there are, "12,000" technical civs in our Galaxy alone, we are unlikely to ever make physical contact with them, or they with us. We all will forever be separated by vast distances of space, and epochs of time.
-- Zen Galacticore