Think about the engineering challenges of building on Mars. The first consideration for any structure is what? Making a foundation that can support the weight of the structure. Even in Mars’ low gravity this will be paramount. Bad foundation? Your structure sinks into the soil. Think: parking a car on a sandy beach. You don’t want to do that for long periods. To avoid this you need to know the strength of the soil, to a depth of many meters. We won’t be successful in building permanent habitats on Mars until we have deep soil cores and we have measured the soil’s strength.
The first things we need to land on Mars, ahead of a human habitat, are a bulldozer, excavator, earth mover, (earth?), and mobile crane. Multiple landers will target one spot to land. But they will likely be tens of meters, or hundreds of meters distant from the other landers. Especially SpaceX with the powerful retro rockets that will push dirt away as they land. Dirt, mind you. Unless we mix concrete and pave a landing pad ahead of time? But then, we don’t know how to mix Martian concrete. Does anyone want to ship concrete from Earth to Mars? Would it work?
So multiple habitats will need to be relocated after they land on Mars. That will require a mobile crane and good road surfaces. Habitats will need to be buried under soil to protect the occupants from radiation. Earth movers and excavators will be necessary.
Then, what happens when the habitat develops a leak outside? Hydraulic leak, or waste water leak, or worse, a leak of breathing air? A buried habitat will be difficult to access the exterior to make repairs. You’ll have to dig down and find the problems.
What would leaking liquids do to the strength of Martian soil? After desiccating for billions of years, I suspect that small drops into the Martian soil would seriously change its physical properties of the soil.
Reading the article about Crispr changes to human genetics and artificial wombs, etc. makes me wonder how many experimental human "mistakes" will end-up in tragic circumstances. We are playing with tools that can make changes that we still do not really understand. It is just recently that scientists have realized that what they used to call "junk DNA" is actually serving various purposes related to how the other DNA (not considered "junk") is expressed in the development and functions of humans. And "the majority" of our DNA is what they considered to be "junk".
My expectation is that people who are unaltered, but selected for physical and mental abilities, will be the crews of scientific missions to Mars as the first step. Whether that leads to a desire for others to try to develop a self-sustaining colony there will depend a lot on what the first scientists actually find.
The density and strength would likely change a lot. How deep would it affect the soil? How would that affect the foundation of the habitat? What would happen if the structure differentially tilts? Are habitats connected by airtight passages? Would those bend?
We’ll need to work out all these little details, and many more. Before anyone can permanently live on Mars.