I think communications will be subject to the laws of physics, given present technology, i.e., the inverse square law will apply. The further out you go, the slower comm will be in inverse proportion to the distance involved. For example, several years ago I was part of a simulation of a mission to Mars. The communications times were done assuming the two planets in conjunction (on opposite sides of the Sun). We used e-mail, rather than voice, and used about 45 minutes delay in replying to a query to Mission Control, Earth, by Mars Base. Thus, between "asked and answered" there was a considerable lapse in time. (I was simulating the Engineering officer at Mission Control.) What made it even more interesting was the fact that the "Mars Base" was actually located up in the foothills west of Denver, and there was IIRC cold and snow up there. They actually had a problem with the furnace, and requested real suggestions to their problem...but agreed to abide by the time delay!
What this will mean to missions further and further out is that they will need to be far more self-sufficient than is currently the case. Think of it like the first settlers to cross the Atlantic Ocean, or settlers crossing the North American continent before the advent of the telegraph!
Frankly, I feel this is the reason why we MUST establish bases on the Moon before proceeding on to Mars or the Near Earth Objects (asteroids)! While many excoriate the "waste of time and money" on the ISS, we have learned to construct complex structures in zero gravity. Some of the problems encountered have not been amenable to training in the neutral boyancy tank at JSC. But we have learned from them!
I believe the same will be true for bases on the Moon, giving us experience for Mars, while still giving us the fall-back position of being able to mount rapid rescue missions and communication that approaches instantaneous in the event of an emergency. At the same time, procedures can be developed for the slower comm times and greater distances!
Mission Control will progress toward being Mission Planning and Operations.
Ad LEO! Ad Luna! Ad Ares! Ad Astra!