"The X-Files" ran for nine seasons (plus a big-screen movie or two) and clearly, it turned many people's brains to mush. Witness the bizarre leaps of logic in the "arguments" of the believers.
Science vlogger Anton Petrov came out with a fascinating new video today, relating Fermi's Paradox to another paradox I had never heard of, Liwenthal's Paradox. It's about the (more than) astronomical number of ways in which a chain of amino acids can fold, yet only one of them results in a functioning protein. For this to happen by random chance would take longer than the present age of the universe, yet it happens regularly inside our bodies and takes only a few milliseconds.
Petrov thinks this is another strong piece of evidence in favor of the "Rare Earth" hypothesis. The emergence of life is so unlikely statistically that it must be rare throughout the universe. I agree, but I also think that Liwenthal's Paradox strengthens the Intelligent Design (ID) hypothesis, or at least keeps it alive.
What if the universe is a giant science experiment conducted by a race of beings with godlike powers? They could have seeded every galaxy with exactly one (1) form of complex life. The lightspeed limit keeps them from interacting in a meaningful way, while their progress in the petri dish that is their galaxy is being monitored by the experimenters.
Pure speculation, of course, but at some distant point in the future what is now a matter of metaphysics may turn into physics based on discoveries we cannot yet imagine.